I hadn't seen Robinson Wood's Frankenstein until it was picked for brickfilm of the week. I had always been a big fan of Grace, even if I do prefer Nathan Well's second-place winning Beast.
However, I might just have to say that I like this film even more than Grace!
Much darker and grittier than his other uber-popular brickfilm, Frankenstein has an overall more consistent artistic style. From the dull grey sets, to the crispy-smooth animation - every frame is like a painting. While the lighting can be a little "flat" in some of the interior scenes - Wood turns around and creates a canvas like that in the shot at 2:46.
Two things are a little sub-par, however... The voice acting, specifically from the character of Victor, and the editing... At least in my opinion.
While I can perfectly understand the voice acting issue and mic quality issues - this was released in 2005, after all. However, the editing issues just seem a bit lazy to me. While I've gotten used to watching brickfilms in a box (youtube/cameras of the time is/are probably the cause of that) it appears that the widescreen letterboxing effect probably was just placed over the centered frames. While this is theoretically a safe move from an editing standpoint, it does lead to shots like at 6:49, which, at least in my opinion, should have looked more like 4:33, only pulled in closer.
However, having eyes at the bottom of the frame easily could have been a stylistic choice, given that it does make it look like Dr. Frankenstein's eyes are only barely looking over a "dark abyss" at the bottom of the screen... Either way, the shot does work in the situation even if I would prefer it a bit differently.
Overall, I think that Frankenstein is a great brickfilm. It certainly deserved first place in the Heroes and Villains contest. It's especially great to watch it around this time of year, and, I look forward to making it a yearly tradition of watching this just before Halloween. 
- Another genius stylistic statement from Robinson Wood.